Many of today’s detection devices can outperform at least certain aspects of human vision by orders of magnitude. They have even shattered our definitions of resolution, since standard definitions of microscope resolution were based on theories that assumed the detection device would be the human eye. In fact, current high-end capture devices constitute a group of hardware and software components adapted for specific types of microscopy. Although we still call these systems cameras, they are a far cry from the film-based cameras with which many of us started our careers. One key component that has undergone rapid evolution is the image capture system. Some new approaches have been made possible by improvements in certain microscope components. The evolution of various super-resolution approaches to microscopy, for instance, are based on radical reconceptualizations of image information collection and analysis. In part this evolution is driven by improvements in components that have allowed microscopists to approach imaging in new and creative ways. How we use them, however, has changed dramatically and continues to evolve at a rapid rate. The basic design of a light microscope has not changed much in the last several decades.
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